?，斘髁质沁x擇性的 CDK4/6 抑制劑，抑制 CDK4/CDK6的 IC50 分別為 2 nM 和 10 nM，是一種治療晚期或轉(zhuǎn)移性乳腺癌的藥物，其適應(yīng)證是HR陽性、HER2陰性的晚期或復(fù)發(fā)乳腺癌。
N-Isopropylacetamide
4-Bromo-2,6-difluoroaniline
6-Bromonicotinaldehyde
4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
6-Aminonicotinaldehyde
6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane)
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
2,4-Dichloro-5-fluoropyrimidine
1-Ethylpiperazine
(E)-n-(4-bromo-2,6-difluorophenyl)-n'-isopropylacetimidamide
1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine
