帕布昔利布是輝瑞公司開發(fā)的ER陽性和HER2陰性乳腺癌的藥物。它是細胞周期蛋白依賴性激酶CDK4和CDK6的選擇性抑制劑。
4-(Cyclopentylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
(E)-But-2-enoic acid
tert-Butyl piperazine-1-carboxylate
tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Tributyl(1-ethoxyvinyl)stannane
tert-Butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Ethyl acetoacetate
5-Bromo-2-nitropyridine
Ethyl 2-(diethoxyphosphoryl)acetate
2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate
5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
1-(6-Nitropyridin-3-yl)piperazine
6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
N,N'-Bis-tert-butoxycarbonylthiourea
5-Bromo-2,4-dichloropyrimidine
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Ethyl 4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carboxylate
2,4-Dichloropyrimidine-5-carbonitrile
Methyl carbamimidothioate sulfate
6-Acetyl-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one
(4-(Cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)methanol
1-(2,4-Dichloropyrimidin-5-yl)ethanone
8-Cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethan-1-one
