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剛性連接子通過引入環(huán)（脂肪環(huán)、脂肪雜環(huán)、芳香環(huán)等）來替代線性連接子，可以有效減少藥物分子中可旋轉(zhuǎn)鍵數(shù)量，限制化合物構象，從而有利于提高藥物分子對靶點的結(jié)合穩(wěn)定性；另一方面，剛性環(huán)相比線性分子更容易調(diào)節(jié)藥物分子的物理化學性質(zhì)，改善其DMPK，目前在蛋白降解劑類藥物中得到廣泛應用。

按化學元素: B^x; C^x; N^x; O^x; F^x; Si^x; P^x; S^x; Cl^x; Br^x; I^x

用途： 脂肪環(huán)連接子 (131) 芳香環(huán)連接子 (128) 脂肪雜環(huán)連接子 (200) 螺環(huán)連接子 (78)

按純度： 99+% 99% 98+% 98% 97+% 97% 96+% 96% 95+% 95% 93% 90+% 90%

默認常備現(xiàn)貨
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清空選項

tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate: BD4457231638765-26-098%; ￥1460.001g常備現(xiàn)貨

Methyl 3-(aminomethyl)bicyclo[1.1.1]pentane-1-carboxylate hydrochloride: BD4457241638761-28-097%; ￥7366.001g常備現(xiàn)貨

tert-Butyl ((3-formylbicyclo[1.1.1]pentan-1-yl)methyl)carbamate: BD4457261638767-79-997%; ￥14006.001g常備現(xiàn)貨

tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate: BD288924203661-71-696%; ￥213.001g常備現(xiàn)貨

2-(4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid: BD122689344933-31-997%; ￥1850.001g常備現(xiàn)貨

4-((Trimethylsilyl)ethynyl)benzaldehyde: BD4200977123-57-095%; ￥1820.00100g常備現(xiàn)貨

Ethyl 2-(trans-4-aminocyclohexyl)acetate: BD22625576308-28-695%; ￥1382.001g常備現(xiàn)貨

Methyl 3-aminocyclobutanecarboxylate hydrochloride: BD2263731354940-69-498%; ￥358.001g常備現(xiàn)貨

cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride: BD2263751212304-86-397%; ￥222.001g常備現(xiàn)貨

4-(1-Boc-4-piperidyl)-1-butanol: BD226419142355-83-798%; ￥629.001g常備現(xiàn)貨

Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride: BD571616333986-70-295%; ￥364.00100mg常備現(xiàn)貨

4-(4-Piperidyl)-1-butanol: BD22659257614-92-398%; ￥3130.005g常備現(xiàn)貨

Methyl (4-cyanophenyl)acetate: BD2894552798-01-396%; ￥530.0010g常備現(xiàn)貨

tert-Butyl 2,8-diazaspiro[4.5]decane-8-carboxylate hydrochloride: BD248571851325-42-397%; ￥4800.005g常備現(xiàn)貨

1,4-Phenylenedimethanamine: BD5361539-48-098%; ￥90.005g常備現(xiàn)貨

tert-Butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate: BD226781918644-73-298%; ￥1251.001g常備現(xiàn)貨

1,4-Benzenediethanol: BD543985140-03-498%; ￥2101.005g常備現(xiàn)貨

[1,1'-Bi(cyclohexane)]-4,4'-diol: BD9198920601-38-195%; ￥33.001g常備現(xiàn)貨

tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate: BD57164161975-39-995%; ￥76.005g常備現(xiàn)貨

4-(Azetidin-3-yl)piperazin-2-one hydrochloride: BD2898411624260-62-395%; ￥3215.001g常備現(xiàn)貨

trans-4-Hydroxycyclohexanecarboxylic acid: BD1548133685-26-598%; ￥65.005g常備現(xiàn)貨

2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid: BD2272531211526-53-297%; ￥370.00250mg常備現(xiàn)貨

2-(4-Cyanophenyl)acetic acid: BD290145462-71-598%; ￥31.00250mg常備現(xiàn)貨

3,3'-(Piperazine-1,4-diyl)dipropanoic acid: BD544285649-49-095%; ￥4226.001g常備現(xiàn)貨

2,2'-(Piperazine-1,4-diyl)diethanol: BD54433122-96-397%; ￥222.00500g常備現(xiàn)貨

3,3'-(Piperazine-1,4-diyl)bis(propan-1-amine): BD544387209-38-398%; ￥87.0025g常備現(xiàn)貨

tert-Butyl 4-(piperidin-3-ylmethyl)piperazine-1-carboxylate: BD5894781211569-09-397%; ￥372.00250mg常備現(xiàn)貨

4-(3-Aminopropyl)aniline: BD22814361798-01-495%; ￥2570.001g常備現(xiàn)貨

Dimethyl trans-1,4-Cyclohexanedicarboxylate: BD1254883399-22-296%; ￥103.0010g常備現(xiàn)貨

tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate: BD2908951363381-95-698%; ￥303.001g常備現(xiàn)貨

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