硼替佐米是有效的 20S 蛋白酶體 (20S proteasome) 抑制劑，Ki 為 0.6 nM，是一種抗腫瘤藥物，是人類應(yīng)用的第一種治療性蛋白酶體抑制劑。蛋白酶體是分解蛋白質(zhì)的細(xì)胞復(fù)合物。在一些癌癥中，通常殺死癌細(xì)胞的蛋白質(zhì)被分解得太快。硼替佐米阻斷了這一過(guò)程，并讓這些蛋白質(zhì)殺死癌細(xì)胞。在美國(guó)和歐洲被批準(zhǔn)用于治療復(fù)發(fā)性多發(fā)性骨髓瘤和套細(xì)胞淋巴瘤。
(R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride
5,5,5',5'-Tetramethyl-2,2'-bi(1,3,2-dioxaborinane)
Isobutylboronic acid
2-Isobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
(1S,2S,3R,5S)-2,6,6-Trimethylbicyclo[3.1.1]heptane-2,3-diol
((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
Pyrazine-2-carboxylic acid
4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane)
(S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoic acid
H-Phe-OMe.HCl
(S)-Methyl 2-amino-3-phenylpropanoate
Boc-Phe-OH
4-(8,9-Dihydropyrido[2,3-b]-1,6-naphthyridin-7(6H)-yl)-4-oxobutanoic acid
3-Methyl-1-(tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride
