含肽段連接子是一類包含特定序列短肽的連接子，這類酶可裂解連接子已廣泛應(yīng)用于抗體偶聯(lián)藥物（ADC）中。ADC的作用機(jī)制是借助抗體的靶向性被精準(zhǔn)的輸送到靶細(xì)胞，接著由內(nèi)吞途徑進(jìn)入細(xì)胞內(nèi)，由于細(xì)胞內(nèi)的溶酶體存在高濃度的蛋白水解酶，從而為含肽鏈連接子提供了在細(xì)胞內(nèi)選擇性裂解的機(jī)會(huì)，最終可以實(shí)現(xiàn)有效載荷的控制性釋放。
(S)-2-(2-(2-Aminoacetamido)acetamido)-N-(2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)-3-phenylpropanamide
1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12-tetraoxapentadecan-15-amide
Azido-peg4-val-cit-pab-oh
4-((14S,17S)-1-Azido-14-isopropyl-12,15-dioxo-17-(3-ureidopropyl)-3,6,9-trioxa-13,16-diazaoctadecan-18-amido)benzyl (4-nitrophenyl) carbonate
4-((S)-2-((S)-2-(3-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl) carbonate
BCN-PEG3-VC-PFP Ester
(S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanoic acid
(5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoyl)-L-valyl-L-arginine
Mal-amido-PEG2-Val-Cit-PAB-OH
