點(diǎn)擊化學(xué)指的是一類模塊化、高選擇性、條件溫和、高產(chǎn)率的偶聯(lián)反應(yīng)，以實(shí)現(xiàn)功能分子的高效快速合成。2022年諾貝爾化學(xué)獎(jiǎng)授予了生物正交反應(yīng)和點(diǎn)擊化學(xué)的開拓者，這兩個(gè)理念均秉持“大道至簡”，即用簡單高效的方法來實(shí)現(xiàn)分子的復(fù)合功能。點(diǎn)擊化學(xué)成功帶領(lǐng)化學(xué)進(jìn)入功能主義時(shí)代，推動(dòng)了材料化學(xué)、化學(xué)生物學(xué)、藥物化學(xué)和生物醫(yī)學(xué)等領(lǐng)域的發(fā)展。
14-Azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate
tert-Butyl 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoate
2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate
1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid
Dbco-c6-nhs ester
1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid
rel-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate
DBCO-PEG4 amine
Exo-BCN-PEG2-Boc-amine
2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
rel-((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate
rel-2,5-Dioxopyrrolidin-1-yl 1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate
Dibenzocyclooctyne-PEG4 maleimide
3-(4-(3,6,9,12-Tetraoxapentadec-14-yn-1-yloxy)phenyl)-6-methyl-1,2,4,5-tetrazine
Methyltetrazine-nhs ester
2-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)acetic acid
Dbco-sulfo-nhs ester
N-(17-Azido-3,6,9,12,15-pentaoxaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
2-(4-(1,2,4,5-Tetrazin-3-yl)phenyl)acetic acid
Adibo-NH-peg2-biotin
2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate
Dbco-peg4-dbco
32-Azido-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontanoic acid
tert-Butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate
O-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)hydroxylamine
2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22-heptaoxapentacos-24-yn-1-oate
tert-Butyl 3,6,9,12,15,18,21-heptaoxatetracos-23-yn-1-ylcarbamate
1-Bromo-3,6,9,12,15,18,21,24,27-nonaoxatriacont-29-yne
2,5-Dioxopyrrolidin-1-yl 2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetate
Propargyl-peg10-amine
